Holders Manchester United might play non-league Eastleigh in the FA Cup fourth round, thus Manchester City will need to break their losing streak at the Tottenham Hotspur Stadium in order to advance.
Since Spurs’ new stadium debuted in 2019, City has lost all five of their prior visits without scoring a goal.
Tottenham, who defeated Burnley 1-0 on Friday to advance to the round of 32, came back from a 3-3 draw in their previous meeting at the Etihad in December.
Later on Monday, United travels to Wigan in League One.
The National League’s Eastleigh and the League Two Newport County will play a third-round rematch on January 16 for the winners.
Chelsea host Aston Villa in the other standout tie.
Maidstone, the only other non-league side still in the draw, travel to Championship high-flyers Ipswich.
Premier League leaders Liverpool will host Norwich or Bristol Rovers after beating Arsenal 2-0 in the pick of the third-round ties.
Draw in full:
Watford v Southampton
Blackburn v Wrexham
Bournemouth v Swansea
West Brom v Brentford or Wolves
West Ham or Bristol City v Nottingham Forest or Blackpool
Leicester v Hull or Birmingham
Sheffield Wednesday v Coventry
Chelsea v Aston Villa
Ipswich v Maidstone
Liverpool v Norwich or Bristol Rovers
Tottenham v Manchester City
Leeds v Plymouth
Crystal Palace or Everton v Luton or Bolton
Newport or Eastleigh v Manchester United
Sheffield United v Brighton
Fulham v Newcastle
Ties to be played over the weekend of January 26-29
