In one of the most anticipated group stage matches in the Europa League, Manchester United will play FC Porto on Thursday night.
In a crucial 20:00 GMT kickoff versus Porto at the Estádio do Dragão takes place in Portugal for the Red Devils, who have had a difficult season.
Porto is a team with a strong record in European competitions, so even if United is the frontrunner, they should expect a tough challenge.
With both teams eyeing progression to the knockout stages, this encounter promises to be a high-stakes affair.
Meanwhile, Tottenham Hotspur will travel to Hungary to take on Ferencvaros.
Spurs are favourites in this matchup and are expected to continue their strong form under their manager, with hopes of securing a vital away win to keep their Europa League campaign on track.
In Italy, Lazio will face a tough test as they host French side Nice.
Both teams have had solid starts to their domestic seasons, and Lazio, as favourites, will look to capitalise on their home advantage in a bid to secure three points.
Spanish side, Real Sociedad, will take on Belgian giants Anderlecht in what is expected to be a high-octane encounter.
Sociedad, playing on home soil, are heavily favoured to win but must be cautious against a resilient Anderlecht side.
Other notable fixtures include Hoffenheim hosting Dynamo Kyiv and Olympiacos taking on SC Braga, with both games also starting at 17:45 GMT.
Galatasaray, fresh off a strong showing, will face Latvian outfit RFS, with the Turkish giants entering the game as favourites.
Later in the evening, attention shifts to matches kicking off at 20:00 GMT, where Roma will travel to Sweden to face Elfsborg. Roma are favourites, but their opponents are expected to put up a strong fight.
Rangers will also be in action, taking on Lyon in what could be one of the standout fixtures of the day.
With several top teams in action and exciting matchups across the board, this round of Europa League games promises drama and plenty of goals as the competition heats up.
